General Resources
Overview
When a child or youth has pain, their pain should be managed using a multimodal, biopsychosocial approach employing physical, psychological, and pharmacologic modalities.
Pharmacologic therapies should begin with nonopioid analgesia whenever possible. For various types of pain adding opioids may sometimes be necessary – this includes moderate to severe short-term pain, or long-term pain.
This toolkit section includes general resources about managing children’s and youths’ pain, and general information about opioid safety.
When opioids are prescribed and administered for pain, there are several considerations to ensure safer therapeutic use:
- Treat pain in a multimodal fashion, combining physical, psychological, and pharmacologic interventions to create the best pain-relief plan for each child/youth
- Physical (e.g., heat, ice, splinting) and psychological (e.g., distraction) treatments should be used for most children and youth with acute pain
- Chronic pain is best managed using combined treatment modalities (e.g., physiotherapy, occupational therapy), non-opioid medications, and counselling, and infrequently requires opioid use
- Non-opioid pharmacologic treatments (e.g., acetaminophen, ibuprofen, other NSAIDs) should be used before or at the same time as opioid options are prescribed
- When needed, opioid analgesia should be combined with non-opioid pharmacologic medications to ensure that only the lowest dose of opioids is used
- Opioid analgesia should be used for as short of a time as possible. As soon as a child or youth’s pain is better managed, they should be transitioned to an alternative non-opioid treatment
- Children, youth and their families should always be counselled about the potential side effects of opioid medications when prescribing or administering opioid analgesia
- Potential for higher-risk opioid use should be assessed using a validated risk assessment tool before prescribing or administering opioid analgesia
- Children and youth who are prescribed opioids for a longer term should be educated about the risks of physical and psychological dependence, as well as withdrawal
Opioids should be prescribed and administered in a culturally safe way.
Also consider risks for opioid use disorder, higher-risk opioid use, child age, and preexisting mental health diagnoses.
However, even when these risks are present, children with severe pain have the right to adequate pain management, which may include the use of opioids. Children and their families should share the decision making about whether opioid analgesia is appropriate for them with their healthcare provider.
“Children’s pain deserves attention and respect. Ignoring and under-treating their pain has important short and long-term effects for both the child’s well-being as well as their ability to get proper healthcare. Dispelling myths and sharing facts through easy-to-use toolkits like this can help make providing better pain care simpler for care providers.”
~ Dr. Samina Ali, Physician

Implicit bias and stigma in healthcare are significant contributors to health inequalities, poor treatment outcomes and avoidance of care.
To ensure equitable access to quality pain management, it is essential to be self-reflective and consider the conscious and unconscious perceptions and attitudes that drive effective and safe opioid prescribing for pain in youth.
There is a need for additional research and resources to address pain- and opioid-related stigma in youth with acute and chronic pain. The following resources contain general information on the role of stigma in the health system. The resources also include recommended ways of communicating about opioid use in compassionate, safe, and non-stigmatizing ways.
Stigma harms patients and considerations are needed for designing and delivering safe and equitable care.
For example, terms such as ‘medical/non-medical substance use’, ‘substance use’, ’substance use disorder’ (when medically accurate), or ‘higher-risk opioid use’ are alternative non-stigmatizing terms as compared with, ‘substance abuse’, ‘substance misuse’, ‘substance habit’ or ‘recreational substance use.’
Substance Use Spectrum, Health Canada, 2022. Visit website
Stigma & Implicit Bias Toolkit, IPRO NQIIC, a Network of Quality Improvement and Innovation Contractor for the U.S. Department of Health and Human Services HHS). 2020. View PDF
Addressing Stigma: Towards a More Inclusive Health System – What We Heard Report, Public Health Agency of Canada. 2019. Visit website
Communicating about Substance Use in Compassionate, Safe and Non-Stigmatizing Ways - A Resource for Canadian Health Professional Organizations and their Membership, Public Health Agency of Canada. 2019. Visit website
Have feedback? Visit linktr.ee/youthinpain or kidsinpain.ca/youth-in-pain to learn more about this toolkit. For content suggestions please e-mail contact@kidsinpain.ca
Resources
Stigma and Opioid Use
Substance Use Spectrum
Health Canada, 2022.
Visit website
Stigma & Implicit Bias Toolkit
IPRO NQIIC, a Network of Quality Improvement and Innovation Contractor for the U.S. Department of Health and Human Services (HHS). 2020.
View PDF
Addressing Stigma: Towards a More Inclusive Health System – What We Heard Report
Public Health Agency of Canada. 2019
Visit website
Communicating about Substance Use in Compassionate, Safe and Non-Stigmatizing Ways - A Resource for Canadian Health Professional Organizations and their Membership
Public Health Agency of Canada. 2019.
Visit website
Statements and Guidelines
The Pediatric Pain Management Standard
CAN/HSO 13200:2023 Pediatric Pain Management Standard
Health Standards Organization. 2023
Access national standard
Best practices in pain assessment and management for children Trottier ED, et al. Paediatrics & Child Health.
Canadian Paediatric Society. 2022
View position statement
The use of oral opioids to control children’s pain in the post-codeine era
Reider MJ & Jong G. Paediatrics & Child Health. Canadian Paediatric Society. 2021
View position statement
Non-prescription pain relief products containing codeine are not recommended for use in people under 18 years of age
Government of Canada. 2020
View public statement
Summary Safety Review - Hydrocodone-containing products - Assessing the Risk of Serious Breathing Problems (respiratory depression) in Children and Adolescents
Government of Canada. 2016
View public statement
Review Articles
Opioid Overdose in the Hospital Setting: A Systematic Review
Danovitch I, et al. Journal of Addiction Medicine. 2020
Access article *subscription-based access
Morphine or hydromorphone: which should be preferred? A systematic review
Spénard S, et al. Archives of Disease in Childhood. 2020
Access article *subscription-based access
Health Professional Resources
Pain treatment bottom line recommendations
Bottom line recommendation for timely and effective multi-modal pain care including pharmacologic treatment for acute pain in pediatric patients.
TREKK and EMSC Innovation and Improvement Centre. 2022
View PDF
Opioids and Children’s Pain
Online infographic that provides information, guidelines, and tools to safely manage opioid prescribing in pediatric patients.
TREKK. 2021
Visit website
Prevention and Treatment of Opioid and Benzodiazepine Withdrawal
Sample guideline on how to wean pediatric patients off opioids and benzodiazepines who are at risk of developing withdrawal symptoms.
SickKids. 2018
View PDF
Pediatric Acute Care Opioid Weaning Guidelines UCSF Benioff Children’s Hospital.
Summary table outlining general guidelines for opioid weaning in pediatric patients.
ChildKind International. 2018
Visit website
Youth and Family Resources
What are Opioids?
A resource for caregivers offering information and guidance on navigating the use of prescribed opioids to treat moderate to severe pain in children.
TREKK. 2021
View website
Opioids don’t have to be scary!
A resource for youth offering information and guidance on navigating the use of prescribed opioids to treat moderate to severe pain.
TREKK. 2021
View website
So you have been prescribed an opioid?
A resource for youth explaining how to safely take prescribed opioid medication, dispelling misconceptions, and tips for communication with healthcare providers.
Reiter E & Ali S. Solutions for Kids in Pain. 2021
View PDF
Question Opioids: A video series
This is a video series aimed at youth and adults to empower them with important information about starting opioids.
The Institute for Safe Medication Practices Canada. 2017
Watch videos
Opioids for pain
Learn why opioids such as morphine, fentanyl and codeine are prescribed and how they help manage pain in children.
About Kids Health. SickKids. 2014
Visit website
Safe opioid checklist for kids
A safety checklist to minimize the risks linked with opioid use.
About Kids Health. SickKids. No Date
View PDF
Additional Resources
Codeine
Government of Canada. 2023
Visit website
5 Questions to ask about my medicines
Institute for Safe Medication Practices Canada. 2021
Visit website
Talking to Your Health Care Provider About Opioids (fact sheet)
Government of Canada. 2020
Visit website
Health Canada advises Canadians to exercise caution when taking gabapentin or pregabalin with opioids
Government of Canada. 2019
View public statement
Patients as the last slice of swiss cheese
He T & Ho C. Hospital News. Institute for Safe Medication Practices Canada. 2017
View PDF
Summary Safety Review - Codeine-containing products - Further Assessing the Risk of Serious Breathing Problems in Children and Adolescents
Government of Canada. 2016
View public statement
Advancing Opioid Safety for Children in Hospitals
The Institute for Safe Medication Practices Canada. 2014
Visit website (multiple languages)
Recognition and Management of Iatrogenically Induced Opioid Dependence and Withdrawal in Children
Galinken J, et al.. Pediatrics. 2014
Access article
Premedication for endotracheal intubation in the newborn infant
Barrington KJ. Canadian Paediatric Society. 2011
View position statement
Opioids
BC Children’s Hospital.
View PDF
Weaning Algorithm for Combination Use of Opioids and Benzodiazepines SickKids.
ChildKind International. No Date
Visit website
Production of this document has been made possible through a financial contribution from Health Canada. The views expressed herein do not necessarily represent the views of Health Canada.